Piperidine-based glycodendrons as protein N-glycan prosthetics
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چکیده
منابع مشابه
SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF N-METHYL PIPERIDINE ANALGESICS
Pain is probably the immediate stimulus for more visits to the Physician's office than all other complaints combined. Since pain serves as an alert to injury, it is often the first harbinger of disease. Piperidine has been extensively utilized for the synthesis of a wide range of therapeutic agents in general and analgetics in particular for the mitigation of pain. In a similar attempt, th...
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In the title compound, C14H19N3O2, the heterocycle adopts a (1)C4 conformation with the N atom being one of the flap atoms. In the crystal, classical N-H⋯O hydrogen bonds and C-H⋯O contacts connect the mol-ecules into a three-dimensional network.
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The title compound, C(11)H(14)N(2)O(2)S, was synthesized from furoyl isothio-cyanate and piperidine in dry acetone. The thio-urea group is in the thio-amide form. The thio-urea group makes a dihedral angle of 53.9 (1)° with the furan carbonyl group. In the crystal structure, mol-ecules are linked by inter-molecular N-H⋯O hydrogen bonds, forming one-dimensional chains along the c axis. An intram...
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CONCLUSION: Our results demonstrate that our novel proprietary scaffold can polarize macrophages to the M2 phenotype and deliver supraphysiologic levels of macrophages to wounds to significantly accelerate wound healing in the absence of adverse effects on scar size and quality. Polarizing macrophages on a scaffold in vivo minimizes time in cell culture and is a desirable method for simultaneo...
متن کاملSurgery as related to prosthetics and orthotics.
The single greatest obstacle to progress in amputation surgery has been the surgeon's lack of prosthetic knowledge . While a small number of surgeons throughout the years have become involved and, in fact, have made significant contributions to prosthetic improvements, the vast majority of amputations continue to be performed by surgeons uninformed in the area of prosthetic rehabilitation . Thi...
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ژورنال
عنوان ژورنال: Bioorganic & Medicinal Chemistry
سال: 2016
ISSN: 0968-0896
DOI: 10.1016/j.bmc.2016.05.050